VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION
Abstract views: 339
/ 
PDF downloads: 285
DOI:
https://doi.org/10.26900/jsp.3.031Keywords:
naproxen, voltammetric method, differential pulse voltammetry, cyclic voltammetry, high performance liquid chromatography, ultra-trace graphite electrode, commercial drug tabletsAbstract
In this work, the electrochemical oxidation of naproxen (NAP) was studied at an ultra-trace graphite electrode (UTGE). The cyclic voltammetry (CV) technique was used to determine the optimum conditions and the effect of pH on the electrochemical oxidation of NAP. Acetate buffer (pH 4.50) was selected as the support electrolyte due to obtaining the highest electronic signal increase during oxidation of NAP at UTGE. The differential pulse voltammetry (DPV) technique was performed for electrochemical determination of NAP. In the optimum conditions, the limits of detection (LOD) and quantification (LOQ) were determined to be 8.6610-8 M and 2.8810-7 M. In addition, the amount of NAP was determined in drug tablets. The recovery studies of NAP from the drug tablet were completed in order to check the accuracy and precision of the applied voltammetric method. Furthermore, the determination of NAP was performed with the high-performance liquid chromatography (HPLC) method. These two methods were compared in terms of accuracy, precision and recovery studies.
Downloads
References
[2] KAYNAK M.S., ŞAHİN S.A., 2008, A new hplc approach for determination of in-vitro solubility of naproxen sodium, J, Hacettepe Univ. J. The Faculty of Pharm. 28, 49
[3] ARESTA A., PALMISANO F., ZAMBONIN C.G., 2005, Determination of naproxen in human urine by solid-phase microextraction coupled to liquid chromatography ,J. Pharm. Biomed. Anal. 39, 643
[4] JAIN N.A., LOHIYA R.T., UMEKAR M.J., 2011, Spectrophotometric determination of naproxen and esomerprazole in a laboratory mixture by simultaneous equation, absorption correction, absorption ratio and area under curve methods, Int. J. Pharma Sci. and Research. 2, 130 (ISSN: 0975-9492)
[5] YILMAZ B., ASCI A., ERDEM A.F., 2014, HPLC method for naproxen determination in human plasma and its application to a pharmacokinetic Study in Turkey J. Chromatogr. Sci. 52, 584
[6] TSVETKOVA B., 2015, RP-HPLC method for determination of naproxen in pharmaceutical dosage form, Pharmacia. 62, 15
[7] UYSAL Ü.D., TUNCEL M., 2004, Determination of naproxen in tablets by using first derivative potentiometry, Turkish J. Pharm. Sci. 1, 217
[8] DAMIANI P., BEARZOTTI M., CABEZÓN M.A., 2002, Spectrofluorometric determination of naproxen in tablets, J. Pharm. Biomed. Anal. 29, 229
[9] SARHANGZADEH K., 2015, Application of multi wall carbon nanotube–graphene hybrid for voltammetric determination of naproxen, J. Iran Chem. Soc. 12, 2133
[10] STEFANO J.S., LIMA A.P., MONTES R.H.O., RICHTER E.M., MUÑOZ R.A.A., 2012, Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection, Braz. Chem. Soc. 23, 1834
[11] SOLTANI N., TAVAKKOLI N., MOSAVIMANESH Z.S., DAVAR F., 2018, Electrochemical determination of naproxen in the presence of acetaminophen using a carbon paste electrode modified with activated carbon nanoparticles,C.R. Chimie, 21, 54
[12] ADHOUM N., MONSER L., TOUMI M., BOUJLEL K., 2003, Determination of naproxen in pharmaceuticals by differential pulse voltammetry at a platinum electrode, Anal. Chim. Acta, 495, 69
[13] SURYANARAYANAN V., ZHANG, YOSHIHARA Y. S., SHIRAKASHI T., 2005, Voltammetric assay of naproxen in pharmaceutical formulations using boron-doped diamond electrode, Electroanalysis, 17, 925
[14] TASHKHOURIAN J., HEMMATEENEJAD B., BEIGIZADEH H., HOSSEINI-SARVARI M., RAZMI Z., 2014, ZnO nanoparticles and multiwalled carbon nanotubes modified carbon paste electrode for determination of naproxen using electrochemical techniques, J. Electroanal. Chem. 714, 103
[15] BEITOLLAHI H., YOONESFAR R., 2016, Fabrication of a novel electrochemical nanosensor for voltammetric determination of naproxen, Anal. Bioanal. Electrochem. 8, 29
[16] AGUILAR-LIRA G.Y., IVAREZ ROMERO G.A., ROJAS-HERNNDEZ A., PEZ-HERNNDEZ M.E., RODRGUEZ-VILA J.A., ROMERO-ROMO M.A., 2014, Voltammetric analysis of naproxen in graphite electrodes and its determination in pharmaceutical samples, Electroanalysis. 26, 1573
[17] SADIKOGLU M., YILMAZ S., KURT I., SELVI B., SARI H., ERDURAN N., USTA E., SAGLIKOGLU G., 2016, Electrocatalytic oxidation of hydrazine on poly (4-aminobenzene sulfonic acid)-modified glassy carbon electrode, Russian J. Electrochem. 52, 603.
[18] CAN S., YILMAZ S., SAGLIKOGLU G., SADIKOGLU M., MENEK N., 2015, Electrocatalytic oxidation of acyclovir on poly (p-aminobenzene sulfonic acid) film modified glassy carbon electrode, Electroanalysis. 27, 2431
[19] YILMAZ S., 2016, Electroanalytical chemistry with example of applied, Gazi book house., Ankara, Turkey, 33.
[20] SKOOG D.A., WEST D.M., HOLLER F.J., CROUCH S.R. 2000, Fundamentals of Analytical Chemistry, Bilim Kitap Kirtasiye Ltd. Sti., Ankara, 158.
Downloads
Published
How to Cite
Issue
Section
License
When the article is accepted for publication in the HSQ authors transfer all copyright in the article to the Holistence Academy Ar-Ge Yazılım Yayıncılık Eğitim Danışmanlık ve Organizasyon Ticaret Ltd. Şti.The authors reserve all proprietary right other than copyright, such as patent rights.
Everyone who is listed as an author in this article should have made a substantial, direct, intellectual contribution to the work and should take public responsibility for it.
This paper contains works that have not previously published or not under consideration for publication in other journals.
