SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION


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Authors

  • A. Hakan AKTAŞ Süleyman Demirel University, Faculty of Science and Arts, Chemistry Department
  • Ümit UÇAR Ms Student

DOI:

https://doi.org/10.26900/jsp2018.8

Keywords:

rosuvastatin, ezetimibe, spectrometry, multivariate calibration

Abstract

Two multivariate calibration-prediction techniques, principal component analysis (PCR) and partial least squares (PLS) were applied to the spectrometric multicomponent analysis of the drug containing rosuvastatin (ROS) and ezetimibe (EZE) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of ROS and EZE were used to check the prediction ability of the PCR and PLS. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the two drugs.

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Published

2018-05-10

How to Cite

AKTAŞ, A. H., & UÇAR, Ümit. (2018). SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION. HEALTH SCIENCES QUARTERLY, 2(2), 1–12. https://doi.org/10.26900/jsp2018.8

Issue

Vol. 2 No. 2 (2018)

Section

Letter to the Editor

License

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