SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION

A. Hakan AKTAŞ; Ümit UÇAR

doi:10.26900/jsp2018.8

SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION

Abstract views: 347 /

PDF downloads: 422

Authors

A. Hakan AKTAŞ Süleyman Demirel University, Faculty of Science and Arts, Chemistry Department
Ümit UÇAR Ms Student

DOI:

https://doi.org/10.26900/jsp2018.8

Keywords:

rosuvastatin, ezetimibe, spectrometry, multivariate calibration

Abstract

Two multivariate calibration-prediction techniques, principal component analysis (PCR) and partial least squares (PLS) were applied to the spectrometric multicomponent analysis of the drug containing rosuvastatin (ROS) and ezetimibe (EZE) without any separation step. The selection of variables was studied. A series of synthetic solution containing different concentrations of ROS and EZE were used to check the prediction ability of the PCR and PLS. The results obtained in this investigation strongly encourage us to apply these techniques for a routine analysis and quality control of the two drugs.

Downloads

Download data is not yet available.

Downloads

Published

2018-05-10

How to Cite

AKTAŞ, A. H., & UÇAR, Ümit. (2018). SPECTROMETRIC DETERMINATION OF ROSUVASTATIN AND EZETIMIBE IN TABLETS BY MULTIVARIATE CALIBRATION. Health Sciences Quarterly, 2(2), 1–12. https://doi.org/10.26900/jsp2018.8

Download Citation

Issue

Vol. 2 No. 2 (2018)

Section

Letter to the Editor

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1. Authors retain copyright and grant the journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) that allows others to share and adapt the work with an acknowledgement of the work's authorship and initial publication in this journal.

2. Everyone who is listed as an author in this article should have made a substantial, direct, intellectual contribution to the work and should take public responsibility for it.