Methotrexate intoxication as a diagnostic challenge: Do patients always tell the truth?


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Authors

DOI:

https://doi.org/10.26900/hsq.2524

Keywords:

methotrexate, intoxication, adverse effect

Abstract

Dear editor,

Methotrexate is an effective and safe drug that has been used for many years in the treatment of psoriasis [1]. Clinical and laboratory monitoring is important for toxicity monitoring in patients. Herein, a case of methotrexate intoxication that developed after long-term uncontrolled and irregular use of methotrexate, but had diagnostic difficulties because the patient concealed this condition in her anamnesis, will be presented.

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References

Yélamos O, Puig L. Systemic methotrexate for the treatment of psoriasis. Expert Rev Clin Immunol. 2015;11(5):553-63.doi: 10.1586/1744666x.2015.1026894.

Fridlington JL, Tripple JW, Reichenberg JS, Hall CS, Diven DG. Acute methotrexate toxicity seen as plaque psoriasis ulceration and necrosis: A diagnostic clue. Dermatology online journal. 2011;17(11)

Weidmann A, Foulkes AC, Kirkham N, Reynolds NJ. Methotrexate toxicity during treatment of chronic plaque psoriasis: A case report and review of the literature. Dermatol Ther (Heidelb). 2014;4(2):145-56.doi: 10.1007/s13555-014-0056-z.

Soon C, Ilchyshyn A. Methotrexate toxicity induced by acute renal failure. J R Soc Med. 2005;98(2):83-4.doi: 10.1177/014107680509800221.

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Published

2025-01-25

How to Cite

Erbağcı, E. (2025). Methotrexate intoxication as a diagnostic challenge: Do patients always tell the truth?. HEALTH SCIENCES QUARTERLY, 5(1), 1–3. https://doi.org/10.26900/hsq.2524

Issue

Vol. 5 No. 1 (2025)

Section

Letter to the Editor

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