Investigation of symptoms and mortality in hypertension patients diagnosed with COVID-19: A retrospective case-control study


Abstract views: 136 / PDF downloads: 116

Authors

DOI:

https://doi.org/10.26900/hsq.2273

Keywords:

COVID-19, Hypertension, symptom

Abstract

It was aimed to determine whether there is a difference in mortality and symptoms between patients, aged 60 years or above, with hypertension (HT) and Coronavirus disease 2019 (COVID-19) infection and those without any chronic disease. The population of the study, which was conducted as a retrospective case-control study, consisted of 2747 HT patients diagnosed with COVID-19 and aged 60 years or above. While 170 patients with HT diagnosis formed the case group, 170 patients without any chronic disease formed the control group from the sample. In this study, the time from diagnosis to death was found to be shorter in the presence of HT in COVID-19 patients, while males diagnosed with COVID-19 had higher rates of intensive care unit admittance, intubation and mortality than females irrespective of HT. The presence of HT was determined not to affect symptoms in patients diagnosed with COVID-19. The most common symptoms were fatigue, cough, body ache, fever, headache, and sore throat in HT and control groups and the symptoms were similar in both groups. Further studies are recommended to reveal the relationship between HT, considered one of the most important risk factors for COVID-19, and adverse outcomes related to COVID-19.

Downloads

Download data is not yet available.

References

Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics-2019 update: A report from the American Heart Association. Circulation. 2019; 139(10):e56-e528. doi: 10.1161/CIR.0000000000000659. DOI: https://doi.org/10.1161/CIR.0000000000000659

Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223-37. doi: 10.1038/s41581-019-0244-2. DOI: https://doi.org/10.1038/s41581-019-0244-2

World Health Organization (2023). Coronavirus disease (COVID-19) outbreak. Retrieved from https://www.who.int/westernpacific/emergencies/covid-19.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727-33. doi: 10.1056/NEJMoa2001017. DOI: https://doi.org/10.1056/NEJMoa2001017

Deng SQ, Peng HJ. Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China. J Clin Med. 2020;9(2):575. doi: 10.3390/jcm9020575. DOI: https://doi.org/10.3390/jcm9020575

Guan W-J, Ni Z-Y, Hu Y, Liang W-H, Ou C-Q, He J-X, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. doi: 10.1056/NEJMoa2002032. DOI: https://doi.org/10.1056/NEJMoa2002032

Peng YD, Meng K, Guan HQ, Leng L, Zhu RR, Wang BY, et al. Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV. Zhonghua Xin Xue Guan Bing Za Zhi. 2020;48(6):450-5. doi: 10.3760/cma.j.cn112148-20200220-00105.

Lian J, Jin X, Hao S, Cai H, Zhang S, Zheng L, et al. Analysis of epidemiological and clinical features in older patients with coronavirus disease 2019 (COVID-19) outside Wuhan. Clin Infect Dis. 2020;71(15):740-7. doi: 10.1093/cid/ciaa242. DOI: https://doi.org/10.1093/cid/ciaa242

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-ınfected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9. doi: 10.1001/jama.2020.1585. DOI: https://doi.org/10.1001/jama.2020.1585

Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clin Res Cardiol. 2020;109(5):531-8. doi: 10.1007/s00392-020-01626-9. DOI: https://doi.org/10.1007/s00392-020-01626-9

Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac ınjury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802-10. doi: 10.1001/jamacardio.2020.0950. DOI: https://doi.org/10.1001/jamacardio.2020.0950

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395(10229):1054-62. doi: 10.1016/S0140-6736(20)30566-3. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5

Deng Y, Liu W, Liu K, Fang YY, Shang J, Zhou L, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: A retrospective study. Chin Med J (Engl). 2020;133(11):1261-7. doi: 10.1097/CM9.0000000000000824. DOI: https://doi.org/10.1097/CM9.0000000000000824

Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-43. doi: 10.1001/jamainternmed.2020.0994. DOI: https://doi.org/10.1001/jamainternmed.2020.0994

Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811-8. doi: 10.1001/jamacardio.2020.1017. DOI: https://doi.org/10.1001/jamacardio.2020.1017

Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: Retrospective study. BMJ. 2020;368: m1091. doi: 10.1136/bmj.m1091. DOI: https://doi.org/10.1136/bmj.m1091

Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87(5):E1-9. doi: 10.1161/01.res.87.5.e1. DOI: https://doi.org/10.1161/01.RES.87.5.e1

Jiang F, Yang J, Zhang Y, Dong M, Wang S, Zhang Q, et al. Angiotensin-converting enzyme 2 and angiotensin 1-7: Novel therapeutic targets. Nat Rev Cardiol. 2014;11(7):413-26. doi: 10.1038/nrcardio.2014.59. DOI: https://doi.org/10.1038/nrcardio.2014.59

Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436(7047):112-6. doi: 10.1038/nature03712. DOI: https://doi.org/10.1038/nature03712

Patel VB, Zhong JC, Grant MB, Oudit GY. Role of the ACE2/angiotensin 1-7 axis of the renin-angiotensin system in heart failure. Circ Res. 2016;118(8):1313-26. doi: 10.1161/CIRCRESAHA.116.307708. DOI: https://doi.org/10.1161/CIRCRESAHA.116.307708

Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260-3. doi: 10.1126/science.abb2507. DOI: https://doi.org/10.1126/science.abb2507

Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, et al. COVID-19 and the cardiovascular system: Implications for risk assessment, diagnosis, and treatment options. Cardiovasc Res. 2020;116(10):1666-87. doi: 10.1093/cvr/cvaa106. DOI: https://doi.org/10.1093/cvr/cvaa106

Badawi A, Ryoo SG. Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): A systematic review and meta-analysis. Int J Infect Dis. 2016;49:129-33. doi: 10.1016/j.ijid.2016.06.015. DOI: https://doi.org/10.1016/j.ijid.2016.06.015

Emami A, Javanmardi F, Pirbonyeh N, Akbari A. Prevalence of underlying diseases in hospitalized patients with COVID-19: A systematic review and meta-analysis. Arch Acad Emerg Med. 2020;8(1):e35. DOI: https://doi.org/10.1371/journal.pone.0241265

Peña JE, Rascón-Pacheco RA, Ascencio-Montiel IJ, González-Figueroa E, Fernández-Gárate JE, Medina-Gómez OS, et al. Hypertension, diabetes and obesity, major risk factors for death in patients with COVID-19 in Mexico. Arch Med Res. 2021;52(4):443-9. doi: 10.1016/j.arcmed.2020.12.002 DOI: https://doi.org/10.1016/j.arcmed.2020.12.002

Liu K, Fang YY, Deng Y, Liu W, Wang MF, Ma JP, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J (Engl). 2020;133(9):1025-31. doi: 10.1097/CM9.0000000000000744. DOI: https://doi.org/10.1097/CM9.0000000000000744

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-5. doi: 10.1016/j.ijid.2020.03.017. DOI: https://doi.org/10.1016/j.ijid.2020.03.017

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study. Lancet Respir Med. 2020;8(5):475-81. doi: 10.1016/S2213-2600(20)30079-5. DOI: https://doi.org/10.1016/S2213-2600(20)30079-5

Du Y, Tu L, Zhu P, Mu M, Wang R, Yang P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan: A retrospective observational study. Am J Respir Crit Care Med. 2020;201(11):1372-9. doi: 10.1164/rccm.202003-0543OC. DOI: https://doi.org/10.1164/rccm.202003-0543OC

Ruan Q, Yang K, Wang W, Jiang L, Song J. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-8. doi: 10.1007/s00134-020-05991-x DOI: https://doi.org/10.1007/s00134-020-05991-x

Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239-42. doi: 10.1001/jama.2020.2648. DOI: https://doi.org/10.1001/jama.2020.2648

Barrera FJ, Shekhar S, Wurth R, Moreno-Pena PJ, Ponce OJ, Hajdenberg M, et al. Prevalence of diabetes and hypertension and their associated risks for poor outcomes in COVID-19 patients. J Endocr Soc. 2020;4(9):bvaa102. doi: 10.1210/jendso/bvaa102. DOI: https://doi.org/10.1210/jendso/bvaa102

Du Y, Zhou N, Zha W, Lv Y. Hypertension is a clinically important risk factor for critical illness and mortality in COVID-19: A meta-analysis. Nutr Metab Cardiovasc Dis. 2021;31(3):745-55. doi: 10.1016/j.numecd.2020.12.009. DOI: https://doi.org/10.1016/j.numecd.2020.12.009

Pranata R, Lim MA, Huang I, Raharjo SB, Lukito AA. Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression. J Renin Angiotensin Aldosterone Syst. 2020;21(2):1470320320926899. doi: 10.1177/1470320320926899. DOI: https://doi.org/10.1177/1470320320926899

Chen Y., Gong X., Wang L., Guo J. Effects of hypertension, diabetes and coronary heart disease on COVID-19 diseases severity: a systematic review and meta-analysis. medRxiv. 2020; doi: 10.1101/2020.03.25.20043133. (preprint). DOI: https://doi.org/10.1101/2020.03.25.20043133

Chen C, Yan JT, Zhou N, Zhao JP, Wang DW. Analysis of myocardial injury in patients with COVID-19 and association between concomitant cardiovascular diseases and severity of COVID-19 [Article in Chinese]. Zhonghua Xin Xue Guan Bing Za Zhi. 2020;48(7):567-71. doi: 10.3760/cma.j.cn112148-20200225-00123.

Shaghee F, Nafakhi H, Al-Buthabhak K, Alareedh M, Nafakhi A, Kasim S. Blood parameters, symptoms at presentation and adverse in-hospital outcomes of COVID-19 pneumonia in patients with hypertension. Arterial Hypertens. 2021;25(1):7-13. doi: 10.5603/AH.a2021.0004 DOI: https://doi.org/10.5603/AH.a2021.0004

Chengyi HU, Lushan X, Hongbo Z, Yanpei Z, Wenfeng Z, Li L, et al. Effect of hypertension on outcomes of patients with COVID-19 [Article in Chinese]. Nan Fang Yi Ke Da Xue Xue Bao. 2020;40(11):1537-42. doi: 10.12122/j.issn.1673-4254.2020.11.01.

Chen F, Sun W, Sun S, Li Z, Wang Z, Yu L. Clinical characteristics and risk factors for mortality among inpatients with COVID‐19 in Wuhan, China. Clin Transl Med. 2020;10(2):e40. doi: 10.1002/ctm2.40. DOI: https://doi.org/10.1002/ctm2.40

Cummings MJ, Baldwin MR, Abrams D, Jacobson SD, Meyer BJ, Balough EM, et al. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. Lancet. 2020;395(10239):1763-70. doi: 10.1016/S0140-6736(20)31189-2. DOI: https://doi.org/10.1016/S0140-6736(20)31189-2

Wang D, Yin Y, Hu C, Liu X, Zhang X, Zhou S, et al. Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. Crit Care. 2020;24(1):188. doi: 10.1186/s13054-020-02895-6. DOI: https://doi.org/10.1186/s13054-020-02895-6

Henry BM, Vikse J, Benoit S, Favaloro EJ, Lippi G. Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis. Clin Chim Acta. 2020;507:167-73. doi: 10.1016/j.cca.2020.04.027. DOI: https://doi.org/10.1016/j.cca.2020.04.027

Vepa A, Bae JP, Ahmed F, Pareek M, Khunti K. COVID-19 and ethnicity: A novel pathophysiological role for inflammation. Diabetes Metab Syndr. 2020;14(5):1043-51. doi: 10.1016/j.dsx.2020.06.056. DOI: https://doi.org/10.1016/j.dsx.2020.06.056

De Miguel C, Rudemiller NP, Abais JM, Mattson DL. Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep. 2015;17(1):507. doi: 10.1007/s11906-014-0507-z. DOI: https://doi.org/10.1007/s11906-014-0507-z

Kulcsar KA, Coleman CM, Beck SE, Frieman MB. Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection. JCI Insight. 2019;4(20): e131774. doi: 10.1172/jci.insight.131774. DOI: https://doi.org/10.1172/jci.insight.131774

Downloads

Published

2024-01-25

How to Cite

Uyar, S., Yalçınkaya, Z., Eti Aslan, F., & Yalın, H. (2024). Investigation of symptoms and mortality in hypertension patients diagnosed with COVID-19: A retrospective case-control study. HEALTH SCIENCES QUARTERLY, 4(1), 21–30. https://doi.org/10.26900/hsq.2273

Issue

Section

Original Article