Assessment of plasma lipid parameters, exhaled nitric oxide fraction, and systemic immune-inflammation index on stable asthma patients
Abstract views: 101 / PDF downloads: 96
Keywords:Asthma, biochemistry, adult, laboratory
Asthma is a chronic disease characterized by the presence of inflammatory agents in the airways, and diagnosis and treatment are based on clinical questioning, physical examination, laboratory results, and spirometric analysis. This study investigated the effect of asthma alone on routine laboratory parameters in adults and whether an idea about the course of the disease can be obtained using these parameters. Two hundred and fourteen patients with known asthma history, diagnosed, and treated according to guidelines, were included in our study. Among all patients and between gender-specific groups, total cholesterol (CHOL), HDL, LDL, VLDL, triglyceride (TG), albumin, total protein (TP), lactate dehydrogenase (LDH), glucose, urea, creatinine, C reactive protein (CRP), FeNO, SII, INR, and complete blood count value parameters of the patients were analyzed. When we consider all asthma patients, we found that the mean glucose, LDH, CRP, TG, FeNO, and INR values outpaced the upper limit of the reference range. In contrast, the mean HDL value was below the reference range for all patients. In addition, our study found a significant correlation between triglyceride levels within the biochemical parameters with FeNO and SII). Finally, when we compared the mean values of gender-specific groups, we found a statistically significant difference between VLDL, HDL, TG, CRP, FeNO, creatinine, lymphocyte, eosinophile, basophile, and hemoglobin. CRP, LDH, TG, FeNO, SII, and INR levels may help clinicians in adult patients with stable asthma. In addition, differences depending on gender could be observed in the biochemical parameters of asthma patients.
Report TG. Global burden of disease due to asthma. 2014; Online at; http://www.globalasthmareport.org/burden/burden.php
Organization WH. Global surveillance, prevention, and control of chronic respiratory diseases: a comprehensive approach; 2007.
Papadopoulos NG, Arakawa H, Carlsen KH, Custovic A, Gern J, Lemanske R. International consensus on (ICON) pediatric asthma. Allergy. 2012;67(8):976-97. doi: 10.1111/j.1398-9995.2012.02865.x.
National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007;120(5):94-138. doi: 10.1016/j.jaci.2007.09.0432015.
Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, et al. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol. 2001;108(5):753-8. doi: 10.1067/mai.2001.119411.
Gibson PG. Use of induced sputum to examine airway inflammation in childhood asthma. J Allergy Clin Immunol. 1998;102(5):100–1. doi: 10.1016/S0091-6749(98)70039-9.
Corren J, Lemanske RF Jr, Hanania NA, Korenblat PE, Parsey MV, Arron JR, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med. 2011;365(12):1088-98. doi: 10.1056/NEJMoa1106469.
MacPherson JC, Comhair SA, Erzurum SC, Klein DF, Lipscomb MF, Kavuru MS, et al. Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: Characterization of pathways available to eosinophils for generating reactive nitrogen species. J Immunol. 2001;166(9):5763-72. doi: 10.4049/jimmunol.166.9.5763.
Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, et al. Asthma outcomes: Biomarkers. J Allergy Clin Immunol. 2012;129(3):9- 23. doi: 10.1016/j.jaci.2011.12.979.
Erdoğan T. Role of systemic immun-inflammation index in asthma and NSAID exacerbated respiratory disease. 22nd Annual Congress with International Participation. Turk Thorac J. doi: 10.5152/TurkThoracJ.2019.30.
Holz O, Jorres RA, Koschyk S, Speckin P, Welker L, Magnussen H. Changes of cellular and biochemical sputum composition during sputum induction in healthy and asthmatic subjects. American Academy of Allergy, Asthma, and Immunology Conference,1996; New Orleans, USA.
Wark PA, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulatio and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J. 2002;19(1):68- 75. doi: 10.1183/09031936.02.00226302.
Usher DJ, Shepherd RJ, Deegan T. Serum lactate dehydrogenase isoenzyme activities in patients with asthma. Thorax. 1974;29(6):685-9. doi: 10.1136/thx.29.6.685.
Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M, et al. High sensitivity C-reactive protein in
asthma. Eur Respir J. 2006;27(5):908-12. doi: 10.1183/09031936.06.00114405.
Çıkrıkçıoğlu BY, Kömürcüoğlu B, Bilaçeroğlu S, Akpınar M, Çelikten E. Serum lipid profile changes in asthma patients during acute attack and stable period (in Turkish). Turk Thorac J. 2003;4(1):7-11.
Guthmann F, Harrach-Ruprecht B, Looman AC, Stevens PA, Robenek H, Rüstow B. Interaction of lipoproteins with type II pneumocytes in vitro: Morphological studies, uptake kinetics and secretion rate of cholesterol. Eur J Cell Biol. 1997;74(2):197-207.
Pian MS, Dobbs LG. Lipoprotein-stimulated surfactant secretion in alveolar type II cells: Mediation by heterotrimeric G proteins. Am J Physiol. 1997;273(3):634-9.
Schouten M, Van De Pol MA, Levi M, Van Der Poll T, Van Der Zee JS. Early activation of coagulation after allergen challenge in patients with allergic asthma. J Thromb Haemost. 2009;7(9):1592-4. doi: 10.1111/j.1538-7836.2009.03523.x.
National Institute for Health and Care Excellence (NICE). NICE guideline. Asthma: diagnosis, monitoring, and chronic asthma management. NICE guideline. 2017. Available from: https:// www.nice.org.uk/guidance/ng80.
Hanania NA, Massanari M, Jain N. Measurement of fractional exhaled nitric oxide in real-world clinical practice alters asthma treatment decisions. Ann Allergy Asthma Immunol. 2018;120(4):414-8. doi: 10.1016/j.anai.2018.01.031.
Abba AA. Exhaled nitric oxide in diagnosis and management of respiratory diseases. Ann Thorac Med. 2009;4(4):173-81. doi: 10.4103/1817-1737.56009.
Hu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20(23):6212-22. doi. 10.1158/1078-0432.CCR14-0442.
How to Cite
Copyright (c) 2022 Holistence Publications
This work is licensed under a Creative Commons Attribution 4.0 International License.
When the article is accepted for publication in the HSQ authors transfer all copyright in the article to the Holistence Academy Ar-Ge Yazılım Yayıncılık Eğitim Danışmanlık ve Organizasyon Ticaret Ltd. Şti.The authors reserve all proprietary right other than copyright, such as patent rights.
Everyone who is listed as an author in this article should have made a substantial, direct, intellectual contribution to the work and should take public responsibility for it.
This paper contains works that have not previously published or not under consideration for publication in other journals.