The prevalence of Asthma-Copd Overlap Syndrome In Women Patients With Biomass Fuel Utilizing
The prevalence of ACOS In Patients With Biomass Fuel
Abstract views: 139
/ 
PDF downloads: 195
DOI:
https://doi.org/10.26900/hsq.1.1.03Keywords:
Chronic obstructive pulmonary disease, asthma, asthma-COPD overlap, biomass smokeAbstract
Objective: Asthma-chronic obstructive pulmonary disease overlap (ACO) indicates that its characteristics with pulmonary exaggerated reactivity and airflow limitation chronically. We aimed to investigate the differences among women non smoker participants who have asthma, chronic obstructive pulmonary disease (COPD) and ACO with biomass smoke exposure.
Method: Patients were examined at the outpatient clinic from September 2017 to March 2020. Non-smoker women patients aged ≥40 years, diagnosed with obstructive pulmonary disease were included in the study. pulmonary function tests (PFT), early reversibility testing (bronchodilator test), and sputum eosinophil analysis were performed to all patients.
Results: A total of 102 patients were included. The mean age was 46.95±9.50 years. In the differential diagnosis, 65 patients (63.7%) had asthma and 37 patients (36.3%) had COPD. Among COPD patients, 10 (27.0%) were diagnosed with ACO. The actual prevalence rates of COPD and ACO were 26.5% and 9.8%, respectively. Poisson regression analysis showed that COPD compared to asthma, while holding the others variable constant in the model, are expected to have 2.976 times greater rate for exacerbations.( IRR, 95%CI ,2.976 (0.687 to 1.494), 5.296 (1.203 to 2.130), P<0.001, Coef. 1.091, 1.667 respectively). Logistic Regression analysis demonstrated that, the count of sputum, blood eosinophil and total IgE results were correlated with the exacerbation times.
Conclusion: Biomass smoke exposure in the women population is revealed as a significant factor for the diagnosis of ACO.
Downloads
References
GOLD. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease (2020 Report). https://goldcopd.org/. Accessed June 25, 2020.
GINA. Global Strategy for Asthma Management and Prevention (2020 Report). https://ginaasthma.org/. Accessed June 25, 2020.
Tan W, Sin D, Bourbeau J, et al. Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study. Thorax. 2015;70(9):822-829.
Baliatsas C, Smit LAM, Dückers M, van Dijk C, Heederik D, Yzermans CJ. Patients with overlapping diagnoses of asthma and COPD: is livestock exposure a risk factor for comorbidity and coexisting symptoms and infections? BMC Pulm Med. 2019. PMID: 31182085
Bruce N, Perez-Padilla R, Albalak R. Indoor air pollution in developing countries: a major environmental and public health challenge. Bull World Health Organ. 2000;78:1078-1092.
Naeher LP, Brauer M, Lipsett M, et al. Woodsmoke health effects: a review. Inhal Toxicol. 2007;19(1):67-106.
Raj TJ. Altered lung function test in asymptomatic women using biomass smoke for cooking. J Clin Diagn Res: JCDR. 2014;8(10):01-03.
Sana A, Somda SM, Meda N, Bouland C. Chronic obstructive pulmonary disease associated with biomass smoke use in women: a systematic review and meta-analysis. BMJ Open Respir Res. 2018;5(1):e000246.
Van den Berge M, Aalbers R. The asthma–COPD overlap syndrome: how is it defined and what are its clinical implications? J Asthma Allergy. 2016;9:27.
Gibson PG, McDonald VM. Asthma–COPD overlap 2015: now we are six. Thorax. 2015;70(7):683-691.
Weiszhar Z, Horvath I. Induced sputum analysis: step by step. ERJ Open Res. 2013.
Bateman ED, Hurd S, Barnes P, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143-178.
Salvi S, Barnes PJ. Is exposure to biomass smoke the biggest risk factor for COPD globally? Chest 2010; 138:3–6.
World Health Organization Programmes. Indoor air pollution. http://www.who.int/indoorair/en/. (Accessed 11 October 2015)
Sussan TE, Ingole V, Kim JH, et al. Source of biomass cooking smoke determinespulmonary response to household air pollution. Am J Respir Cell Mol Biol 2014; 50:538–548.
Guarnieri MJ, Diaz JV, Basu C, et al. Effects of woodsmoke exposure on airwayinflammation in rural Guatemalan women. PLoS One 2014; 9:e88455.
Mehra D, Geraghty PM, Hardigan AA, Foronjy R. A comparison of theinflammatory and proteolytic effects of dung biomass and cigarette smok eexposure in the lung. PLoS One 2012; 7:e52889.
Awji EG, Chand H, Bruse S, et al. Wood smoke enhances cigarette smokeinducedinflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells. Am J Respir Cell Mol Biol 2015; 52:377–386
Postma DS, Rabe KF. The asthma-COPD overlap syndrome. N Engl J Med 2015; 373:1241–1249.
Solleiro-Villavicencio H, Quintana-Carrillo R, Falfan-Valencia R, Vargas-RojasMI. Chronic obstructive pulmonary disease induced by exposure to biomasssmoke is associated with a Th2 cytokine production profile. Clin Immunol2015; 161:150–155
Da Silva LF, Saldiva SR, Saldiva PH, Dolhnikoff M. Impaired lung function inindividuals chronically exposed to biomass combustion. Environ Res 2012;112:111–117.
Kurmi OP, Semple S, Simkhada P, et al. COPD and chronic bronchitis risk ofindoor air pollution from solid smoke: a systematic review and meta-analysis.Thorax 2010; 65:221–228.
Hu G, Zhou Y, Tian J, et al. Risk of COPD from exposure to biomass smoke: ameta-analysis. Chest 2010; 138:20–31.
Koksal H, Saygi A, Sariman N, et al. Evaluation of clinical and functionalparameters in female subjects with biomass smoke exposure. Respir Care2013; 58:424–430
Falfán-Valencia R, Ramírez-Venegas A, Pérez Lara-Albisua JL, Ramírez-Rodriguez SL, Márquez-García JE, Buendía-Roldan I, Gayosso-Gómez LV, Pérez-Padilla R, Ortiz-Quintero B. Smoke exposure from chronic biomass burning induces distinct accumulative systemic inflammatory cytokine alterations compared to tobacco smoking in healthy women,Cytokine. 2020 Jul;131:155089. doi: 10.1016/j.cyto.2020.155089. Epub 2020 Apr 10.
Gunen H, Hacievliyagil SS, Yetkin O, Gulbas G, Mutlu LC, Pehlivan E. Prevalence of COPD: first epidemiological study of a large region in Turkey. Eur J Intern Med. 2008;19(7):499-504.
Golpe R, Suarez-Valor M, Martin-Robles I, et al. Mortality in COPD patients according to clinical phenotypes. Int J Chron Obstruct Pulmon Dis. 2018;13:1433–1439. doi:10.2147/COPD. S159834.
Mendy A, Forno E, Niyonsenga T, et al. Prevalence and features of asthma-COPD overlap in the United States 2007-2012. Clin Respir J. 2018;12(8):2369–2377. doi:10.1111/crj.1291
Park HY, Lee SY, Kang D, et al. Favorable longitudinal change of lung function in patients with asthma-COPD overlap from a COPD cohort. Respir Res. 2018;19(1):36. doi:10.1186/s12931- 018-0737-8.
Kitaguchi Y, Yasuo M, Hanaoka M. Comparison of pulmonary function in patients with COPD, asthma-COPD overlap syndrome, and asthma with airflow limitation. Int J Chron Obstruct Pulmon Dis. 2016;11:991.
Soler-Cataluna JJ, Cosío B, Izquierdo JL, et al. Consensus document on the overlap phenotype COPD–asthma in COPD. Arch Bronconeumol. (English Edition). 2012;48(9):331-337.
Sin DD, Miravitlles M, Mannino DM, et al. What is asthma− COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J. 2016;48(3):664-673.
Bafadhel M, McKenna S, Terry S, et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med. 2011;184(6):662-671.
Negewo NA, McDonald VM, Baines KJ, et al. Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:1495.
De Marco R, Pesce G, Marcon A, et al. The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population. PloS one. 2013;8(5):e62985.
Rhee CK, Yoon HK, Yoo KH, et al. Medical utilization and cost in patients with overlap syndrome of chronic obstructive pulmonary disease and asthma. COPD. 2014;11(2):163-170.
Zhou Z, Zhou A, Peng Y, Duan J, Zeng Y, Zhao Y, Cheng W, Chen P, Determinants of Clinical COPD Questionnaire in Patients with COPD: A Cross-Sectional Observational Study..Respiration. 2020 Jul 13:1-11. doi: 10.1159/000507097. Online ahead of print.PMID: 32659763
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Holistence Publications
This work is licensed under a Creative Commons Attribution 4.0 International License.
When the article is accepted for publication in the HSQ authors transfer all copyright in the article to the Holistence Academy Ar-Ge Yazılım Yayıncılık Eğitim Danışmanlık ve Organizasyon Ticaret Ltd. Şti.The authors reserve all proprietary right other than copyright, such as patent rights.
Everyone who is listed as an author in this article should have made a substantial, direct, intellectual contribution to the work and should take public responsibility for it.
This paper contains works that have not previously published or not under consideration for publication in other journals.
