DETERMINATION OF CLOMIPRAMINE HYDROCHLORIDE FROM ITS COMMERCIAL DRUG FORM BY VOLTAMMETRY
Views
570
Abstract
In this study, electroanalytical technique was developed for the quantitative analysis of clomipramine hydrochloride from its commercial tablet dosage forms based on its oxidation behavior. The electrochemical determination of clomipramine hydrochloride was easily carried out on glassy carbon electrode (GCE) by two voltammetric techniques. The electrochemical measurements were carried out on GCE surface in different buffer solutions in the pH range from 2.00 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The efect of pH on the anodic peak current and peak potential was investigated. Phosphate buffer (pH 6.50) was selected for analytical purposes. The diffusion-controlled nature of the peak was obtained. A linear calibration plot for DPV analysis was constructed in the clozapine concentration range from 5x10-6 mol L-1 to 3x10-5 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 2.8x10-7 mol L-1 and 8.4x10-7 mol L-1 respectively. Validation of applied voltammetric techniques was applied.
Keywords:
clomipramine hydrochloride oxidation voltammetry GCE electrochemical analysisDownloads
Downloads
Published
Issue
Section
How to Cite
License
Copyright (c) 2018 Holistence Publications
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication, with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) that allows others to share and adapt the work with an acknowledgement of the work's authorship and initial publication in this journal.
2. Everyone who is listed as an author in this article should have made a substantial, direct, intellectual contribution to the work and should take public responsibility for it.
