MORPHOMETRIC ANALYSIS OF THE WHITE MATTER STRUCTURES IN FEMALE MIGRAINE PATIENTS
Abstract views: 179
/ 
PDF downloads: 210
DOI:
https://doi.org/10.26900/jsp.5.1.06Keywords:
Migraine, Internal Capsule, Corpus Callosum, Morphometry, MRAbstract
Migraine is a multifactorial neurovascular syndrome characterized by typical headache attacks that occur with internal and external triggering factors in individuals with genetic susceptibility. It affects more than 12% of the general population. The aim of the present study is to compare the morphometric measurements of the determined white matter structures with the control group to investigate whether there is a structural difference in white matter structures in female patients with migraine.
The width of the internal capsule parts (anterior limb, posterior limb and genu) and genu angle was evaluated through MRI. Corpus callosum related measurements were determined in the sagittal section. It was manually traced following its edge on the midsagittal slice of T1 images, where its structure appeared most remarkable. The right and left internal capsule related measurements were compared with migraine and control groups. Except the genu angle, there were statistically significant difference between all measurements and widths in the migraine group were greater than controls. No significant difference was found between the corpus callosum related measurements in the comparison of both groups.
Internal capsule consists of several essential white matter fiber bundles of the brain, and is strongly connected between a range of cortical and subcortical anatomical structures. It has a crucial importance for brain functions and it can be affected by a variety of pathologies. The corpus callosum is the main fiber tract connecting two hemispheres with extensive connections and is topographically organized. It has been investigated in several neurodegenerative diseases as a marker for cortical pathology.
Knowing the white matter structure in migraine patients, determining its prevalence, and its correlation with the severity, type and duration of migraine can give an idea to clinicians.
Downloads
References
BURING, J.E., HEBERT, P., ROMERO, J., KITTROSS, A., COOK, N., MANSON, J., et al. (1995). Migraine and subsequent risk of stroke in the physicians’ health study. Arch Neurol, 52(2), 129-134.
CHANG, C.L., DONAGHY, M. & POULTER, N. (1999). Migraine and stroke in young women: case-control study: The World Health Organisation collaborative study of cardiovascular disease and steroid hormone contraception. BMJ, 318, 13-18.
CHOWDHURY, F., HAQUE, M., SARKAR, M., ARA, S. & ISLAM, M. (2010). White fiber dissection of brain; the internal capsule: a cadaveric study. Turk Neurosurg, 20, 314–322.
DEL ZOTTO, E., PEZZINI, A., GIOSSI, A., VOLONGHI, I. & PADOVANI, A. (2008). Migraine and ischemic stroke: a debated question. journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism; 28(8), 1399-1421.
ERTAS, M., BAYKAN, B., ORHAN, E.K., ZARIFOGLU, M., KARLI, N., SAIP, S. et al. (2012). One-Year prevalence and the impact of migraine and tension-type headache in turkey: a nationwide home-based study in adults. The Journal of Headache and Pain, 13(2), 147-157.
EVANS, R.W., BURCH, R.C., FRISHBERG, B.M., MARMURA, M.J., MECHTLER, L.L., SILBERSTEIN, S.D., TURNER, D.P. (2020). Neuroimaging for migraine: the American headache society systematic review and evidence-based guideline. Headache, 60(2), 318-336.
FRAZIER, T.W. & HARDAN, A.Y. (2009). A meta-analysis of the corpus callosum in autism. Biol Psychiatry, 66(10), 935-941.
GAZZANIGA, M.S. (2000). Cerebral specialization and interhemispheric communication: Does the CC enable the human condition? Brain, 123(7), 1293-1326.
HOFER, S. & FRAHM, J. (2006). Topography of the human corpus callosum revisited-comprehensive fibre tractography using diffusion tensor magnetic resonance imaging. Neuroimage, 32(3), 989-994.
HYETT, M.P., PERRY, A., BREAKSPEAR, M., WEN, W. & PARKER, G.B. (2018). White Matter Alterations in the Internal Capsule and Psychomotor Impairment in Melancholic Depression. PLoS One; 13(4): e0195672.
LEONARDI, M., STEINER, T.J., SCHER, A.T. & LIPTON, R.B. (2005). The global burden of migraine: measuring disability in headache disorders with WHO's classification of functioning, disability and health (ICF). The Journal of Headache and Pain, 6(6), 429-440.
LONGSTRETH, WT J.R., MANOLIO, T.A., ARNOLD, A., BURKE, G.L., BRYAN, N., JUNGREIS, C.A., ENRIGHT, P.L., O'LEARY, D. & FRIED, L. (1996). Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke, 27(8):1274-1282.
LIPTON, R.B., STEWART, W.F., DIAMOND, S., DIAMOND, M.L. & REED, M. (2001). Prevalence and burden of migraine in the United States: Data from the American Migraine Study II. Headache, 41(7), 646-657.
LIPTON, R.B. & BIGAL, M.E. (2005). Migraine: epidemiology, impact, and risk factors for progression. Headache, 45 Suppl 1, S3-s13.
LIPTON, R.B., BIGAL, M.E., DIAMOND, M., FREITAG, F., REED, M.L. & STEWART, W.F. (2007). Migraine prevalence, disease burden, and the need for preventive therapy. Neurology; 68(5):343-349.
MATHARU, M.S., GOOD, C.D., MAY, A., BAHRA, A. & GOADSBY, P.J. (2003). No change in the structure of the brain in migraine: a voxel-based morphometric study. Eur J Neurol, 10(1), 53-57.
OVER, F., BICAKCI, S., SARICA, Y. & SERTDEMIR, Y. (2007). Beyaz cevher lezyonları ve migren. Türk Nörol Derg; 13, 201–206.
PALM-MEINDERS, I.H., KOPPEN, H., TERWINDT, G.M, et al. (2012). Structural brain changes in migraine. JAMA, 308(18), 1889-1897.
QUIGLEY, M., CORDES, D., TURSKI, P., et al. (2003). Role of the corpus callosum in functional connectivity. AJNR Am J Neuroradiol, 24(2), 208-212.
ROPPER, A.H. & SAMUELS, M.A. (2011). Adams and Victor's Principles of Neurology. Çeviri editörü: Murat Emre.
RUSSELL, M., IVERSEN, H.K. & OLESEN, J. (1994). Improved description of the migraine aura by a diagnostic aura diary. Cephalalgia, 14(2), 107-117.
SCHER, AI., GUDMUNDSSON, LS., SIGURDSSON, S. et al. (2009). Migraine headache in middle age and late-life brain infarcts. JAMA, 301(24), 2563-2570.
SCHMITZ, N., ADMIRAAL‐BEHLOUL, F., ARKINK E.B. et al. (2008). Attack frequency and disease duration as indicators for brain damage in migraine. Headache: The Journal of Head and Face Pain. 48(7),1044-1055.
SWARTZ, R.H. & KERN, R.Z. (2004). Migraine is associated with magnetic resonance imaging white matter abnormalities: A meta-analysis. Arch Neurol, 61(9), 1366-1368.
TURAMANLAR, O., BILIR, A., HORATA, E., ERTEKIN, T., OZER GOKASLAN, Ç. & EMEKSIZ, H. (2020). Morphometry of the internal capsule on MR images in adult healthy individuals. Anatomy, 14(1), 49-52.
UNLU, E., BAGCIOGLU, E., ACAY, M.P. et al. (2014). Magnetic resonance imaging study of corpus callosum abnormalities in patients with different subtypes of schizophrenia. S Afr J Psychiatr, 20(4), 146-152.
WILTSHIRE, K., FOSTER, S., KAYE, J.A., SMALL, B.J., CAMICIOLI, R. (2005). Corpus callosum in neurodegenerative diseases: findings in Parkinson's disease. Dement Geriatr Cogn Disord, 20(6), 345-351.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Holistence Publications
This work is licensed under a Creative Commons Attribution 4.0 International License.
When the article is accepted for publication in the HSQ authors transfer all copyright in the article to the Holistence Academy Ar-Ge Yazılım Yayıncılık Eğitim Danışmanlık ve Organizasyon Ticaret Ltd. Şti.The authors reserve all proprietary right other than copyright, such as patent rights.
Everyone who is listed as an author in this article should have made a substantial, direct, intellectual contribution to the work and should take public responsibility for it.
This paper contains works that have not previously published or not under consideration for publication in other journals.
