VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION


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Authors

DOI:

https://doi.org/10.26900/jsp.3.031

Keywords:

naproxen, voltammetric method, differential pulse voltammetry, cyclic voltammetry, high performance liquid chromatography, ultra-trace graphite electrode, commercial drug tablets

Abstract

In this work, the electrochemical oxidation of naproxen (NAP) was studied at an ultra-trace graphite electrode (UTGE). The cyclic voltammetry (CV) technique was used to determine the optimum conditions and the effect of pH on the electrochemical oxidation of NAP. Acetate buffer (pH 4.50) was selected as the support electrolyte due to obtaining the highest electronic signal increase during oxidation of NAP at UTGE. The differential pulse voltammetry (DPV) technique was performed for electrochemical determination of NAP. In the optimum conditions, the limits of detection (LOD) and quantification (LOQ) were determined to be 8.6610-8 M and 2.8810-7 M. In addition, the amount of NAP was determined in drug tablets. The recovery studies of NAP from the drug tablet were completed in order to check the accuracy and precision of the applied voltammetric method. Furthermore, the determination of NAP was performed with the high-performance liquid chromatography (HPLC) method. These two methods were compared in terms of accuracy, precision and recovery studies.

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Author Biographies

Selehattin YILMAZ, Çanakkale Onsekiz Mart University/Turkey

** Department of Chemistry, Faculty of Science and Arts, University of Canakkale Onsekiz Mart, TURKEY, e-mail: seletyilmaz@hotmail.com

ORCID ID: https://orcid.org/0000-0003-4607-3523

Suzan YANIK, Çanakkale Onsekiz Mart University/Turkey

* Department of Chemistry, Faculty of Science and Arts, University of Canakkale Onsekiz Mart, TURKEY, e-mail: suzan.yanik@gmail.com

ORCID ID: https://orcid.org/0000-0002-0532-4149

Gulsen SAGLIKOGLU, Çanakkale Onsekiz Mart University/Turkey

*** Department of Chemistry, Faculty of Science and Arts, University of Canakkale Onsekiz Mart, TURKEY, e-mail: gulsensaglikoglu@hotmail.com

ORCID ID: https://orcid.org/0000-0002-3407-9787

Murat SADIKOGLU, Çanakkale Onsekiz Mart University/Turkey

**** Department of Science Education, Faculty of Education, University of Tokat Gaziosmanpasa, TURKEY, e-mail: murat.sadikoglu@yahoo.com

ORCID ID: https://orcid.org/0000-0002-6701-6838

Ozlem TONGUC YAYINTAS, Çanakkale Onsekiz Mart University/Turkey

***** Canakkale Onsekiz Mart University, School of Applied Sciences, Department of Fisheries Technology, TURKEY, e-mail: ozlemyayintas@hotmail.com

ORCID ID: https://orcid.org/0000-0002-3554-1881

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Published

2019-10-29

How to Cite

YILMAZ, S., YANIK, S., SAGLIKOGLU, G., SADIKOGLU, M., & TONGUC YAYINTAS, O. (2019). VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION. HEALTH SCIENCES QUARTERLY, 3(4), 299–310. https://doi.org/10.26900/jsp.3.031

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