HEALTH SCIENCES QUARTERLY 2022-04-24T00:00:00+00:00 Buse AZLAĞ Open Journal Systems <p><strong>About the HSQ</strong></p> <p>Health Sciences Quarterly (E-ISSN: <a href="" target="_blank" rel="noopener">2791-6022</a>) journal as known by the name of "Journal of Scientific Perspectives" until April 2021 which has been published since 2017 is an international peer-reviewed journal of HOLISTENCE PUBLICATIONS. It is published quarterly in January, April, July, and October. All manuscripts submitted for publication are evaluated by the editor-in-chief, section editor, editorial board, and referees. In addition, the journal provides a medium for highlighting selected articles reporting highly significant original findings, as Editor's Choice Manuscripts.</p> Vocal cord hemangioma 2022-02-02T15:10:12+00:00 Inês Chang Mendes Patrícia Melo Sousa José Ezequiel Barros <p>Hemangiomas of the larynx can be divided in two main forms: infantile and adult. The infantile form is more common in the subglottis and the adult form is usually found at or above the level of the vocal cords. Laryngeal hemangioma of the vocal cord is a very rare condition. We present a case of a 39-year-old female with a large hemangioma of the left vocal cord causing hoarseness and respiratory distress. The lesion was surgically removed successfully at our center.</p> 2022-04-24T00:00:00+00:00 Copyright (c) 2022 Holistence Publications A qualitative research on the acculturation strategies, risk factors and health perceptions of Syrian asylum seekers 2022-03-18T08:12:09+00:00 Dilek Nural Arslan Şafak Dağhan <p>The internal turmoil, that broke out in Syria, started a mass migration movement towards Turkey in 2011. This migration movement, which proved to be an important social phenomenon, individuals from many different cultures have experienced coexistence for compulsory reasons. On top of that experience they were subjected to, the addition of a highly complicated process of acculturation, and the risk factors which immigrants and ethnic minority groups faced caused them to classify as vulnurable regarding health. The aim of this study is to assess how the preferred acculturation strategy of Syrian asylum seekers, who found themselves living along with different cultures, their negative or positive experiences and the risk factors they face affects their health, and health perceptions. The research was designed as a phenomenological research. In-depth interviews were conducted with 24 participants, who were included in the study, using the purposive sampling strategies, homogeneous case sampling and criterion sampling technique. In addition to the usage of code book obtained from the literary works related to the field using the deductive method, the data recorded by observing and the notes from interviews were reduced to themes, categories and codes using the inductive method. The study is grouped under three main themes, namely acculturation strategy of Syrian asylum seekers, risk factors affecting the healths of Syrian asylum seekers and health perception of Syrian asylum seekers. Statistical analysis of the data was carried out by using descriptive analysis and content analysis provided in the MAXQDA 2020 pro-package program. Although the participants heavily express their opinions in favor of seperationg strategy, which is one of the acculturation strategies, this is followed by an integration strategy. Furthermore, the participants were observed to have been subjected to discrimination and rejection, and in this process, facing risk factors mainly social, psychological, environmental, physical and barriers affecting healthcare procurement. Multiple relational analysis show that an intense relationship was found between the participants who preferred the separatist strategy and the risk factors affecting their health. It was observed that the participants who reported good health perception before migrating; due to the most reported social risk factor, economic barriers, reported negative health perception after migrating. The majority of participants who preferred the integration strategy reported good health perception both before and after migration.</p> 2022-04-24T00:00:00+00:00 Copyright (c) 2022 Holistence Publications Prevalence, symptom and severity of COVID 19 among permanent residents of Dhaka City 2022-03-21T14:32:06+00:00 Shamima Parvin Lasker Rahman Shah Mahfuzur Md Jafurullah Md Abdul Jalil Ansari Arif Hossain <p>A study was done on 385 people who survived from COVID 19 to assess the prevalence, symptom, and severity of COVID 19 of permanent residents of Dhaka city, Bangladesh during the second wave of corona manifestation. Data were collected purposively from a government and a private hospital, and general people taking treatment from home. A significant number of respondents took treatment from the Hospital during 2nd wave of COVID 19. Two-third of participants endured moderate (67.5%) type of suffering followed by mild (18.7%) and severe (13.8%) type of suffering. Most of the participants were married (88.8%) and female (51.2%). There was no significant difference between females and males suffering and the risk and severity of COVID 19 (p=694). Most of the participants (70%) had comorbidity. Time to recover from symptoms had significant relation with symptom patterns. One-third of the respondents (33%) required 4-7 days to recover from suffering. A little higher than a quarter (27.8%) recovered within 8 to 14 days and more than a quarter 105 (27.3%) recovered by 8-12 days respectively. Most of the respondents had a fever, cough, body ache and fatigue, sore throat, and breathing difficulty. Only (7.3%) had diarrhea (3.9%) and smell loss 13 (3.4%). People of permanent residence of Dhaka city suffered from COVID 19 irrespective of sex, education, professional status. They had comorbidity, required 8-14 days of hospitalization, and endured the moderate type of suffering of COVID-19.</p> 2022-04-24T00:00:00+00:00 Copyright (c) 2022 Holistence Publications Bionic construction of the human body in the light of the slippery slope argument 2022-02-28T07:19:10+00:00 Şükrü Keleş <p>Composite tissue transplantation has gained a new dimension in line with advanced technological developments. In extremity losses, the traditionally implemented procedure is to enable the extremity to regain its functionality through replantation instead of transplantation. On the other hand, innovative studies are also carried out to support and strengthen the human body and improve the problematic body functions for increasing patients’ quality of life. Studies on developing biomechatronic systems, which are related to biology, neurology, biophysics, mechanics, biomedical and tissue engineering, electronics, and computer sciences, are in progress, which indicates that a transformation has occurred in the approaches to composite tissue transplantation. This study aims to generate ideas about determining a conventional limit in the interventions towards the human body against the technological and scientific developments and to perform a value analysis on such interventions. This study was designed within the framework of the methodology of medical ethics and in the light of the slippery slope argument. The process of transformation from the medical procedures that aim to protect patients’ bodily integrity to the innovative practices that provide an opportunity to bionically turn healthy human bodies into the half machine and half-human is investigated in the light of the slippery slope argument. This study indicated that the value-related problems regarding this issue are related to the principles of respect for autonomy, beneficence, non-maleficence, and justice. The limit to be determined for the practices that aim to protect the patients’ bodily integrity and increase their quality of life and that are not life-saving depends on the distinction between an ill body and a healthy body. A meticulous clinical perspective and legislative regulations that prevent the instrumentalization of humans are required so as not to roll down to undesirable places on a slope. Advanced technological developments are implemented in medicine, protecting human dignity should be adopted as a fundamental value.</p> 2022-04-24T00:00:00+00:00 Copyright (c) 2022 Holistence Publications Reciprocal regulation of glycogen synthase kinase-3 and β-catenin affects cell proliferation of fructose treated rat hepatocytes 2022-03-22T07:31:28+00:00 Gökhan Sadi Aykut Bostancı <p>High consumption of fructose might lead to obesity, diabetes, and metabolic syndrome in the long term. Recent studies demonstrated the induction of insulin resistance in the liver tissues by down-regulation of insulin signaling pathway elements. Glycogen synthase kinase-3 (GSK-3), one of the insulin signaling elements, suppresses the β-catenin function that is required for cell proliferation and integrity. This study is designed to demonstrate the effects of fructose on the proliferation of rat hepatocytes and its effects on GSK-3 and β-catenin expression. Accordingly, rat hepatocytes were treated with different concentrations of fructose, and cell proliferation was followed with an xCELLigence real-time cell analysis system. Besides, gene and protein expression levels of GSK3β and β-catenin were evaluated in fructose-treated cells with qRT-PCR and Western blot, respectively. The results demonstrated proliferative effects of fructose at low doses (0-25-50 mM), but cytotoxic properties are pronounced at higher doses (100-150 mM). The IC50 value was calculated as 140±7 mM fructose for Clone-9 cells. Molecular effects of fructose over GSK-3β and β-catenin appeared at gene and protein levels at 100- and 150-mM concentrations at which GSK-3β were suppressed. Conversely, high-dose fructose leads to β-catenin induction as a compensatory mechanism to counteract the antiproliferative effects of fructose at these doses. In conclusion, high-dose fructoseinduced cytotoxicity activates a compensatory molecular mechanism involving β-catenin induction which might protect the cells in the long-term fructose exposure</p> 2022-04-24T00:00:00+00:00 Copyright (c) 2022 Holistence Publications Assessment of plasma lipid parameters, exhaled nitric oxide fraction, and systemic immune-inflammation index on stable asthma patients 2022-02-01T18:59:59+00:00 Muhammed Emin Düz Aydın Balcı <p>Asthma is a chronic disease characterized by the presence of inflammatory agents in the airways, and diagnosis and treatment are based on clinical questioning, physical examination, laboratory results, and spirometric analysis. This study investigated the effect of asthma alone on routine laboratory parameters in adults and whether an idea about the course of the disease can be obtained using these parameters. Two hundred and fourteen patients with known asthma history, diagnosed, and treated according to guidelines, were included in our study. Among all patients and between gender-specific groups, total cholesterol (CHOL), HDL, LDL, VLDL, triglyceride (TG), albumin, total protein (TP), lactate dehydrogenase (LDH), glucose, urea, creatinine, C reactive protein (CRP), FeNO, SII, INR, and complete blood count value parameters of the patients were analyzed. When we consider all asthma patients, we found that the mean glucose, LDH, CRP, TG, FeNO, and INR values outpaced the upper limit of the reference range. In contrast, the mean HDL value was below the reference range for all patients. In addition, our study found a significant correlation between triglyceride levels within the biochemical parameters with FeNO and SII). Finally, when we compared the mean values of gender-specific groups, we found a statistically significant difference between VLDL, HDL, TG, CRP, FeNO, creatinine, lymphocyte, eosinophile, basophile, and hemoglobin. CRP, LDH, TG, FeNO, SII, and INR levels may help clinicians in adult patients with stable asthma. In addition, differences depending on gender could be observed in the biochemical parameters of asthma patients.</p> 2022-04-24T00:00:00+00:00 Copyright (c) 2022 Holistence Publications