@article{Genç Çetin_Şentük_Aydın_2021, title={EVALUATION OF THE RELATIONSHIP BETWEEN IL-10, IL-17, IL-23 LEVELS AND DISEASE ACTIVITY OF SYSTEMIC LUPUS ERYTHEMATOSUS AND VITAMIN D STATUS}, volume={1}, url={https://journals.gen.tr/index.php/jsp/article/view/1376}, DOI={10.26900/hsq.1.1.05}, abstractNote={<p><strong><em>Introduction:</em></strong><em> Systemic lupus erythematosus (SLE) is a multisystemic, autoimmune connective tissue disease characterized by a variable course and prognosis. We aimed to determine IL-10, IL-17 and IL-23 cytokines and vitamin D levels in SLE patients, which we think play role in the pathogenesis of the disease.</em></p> <p><strong><em>Material and Method:</em></strong><em> Forty SLE patients and 20 healthy controls were included in our study. Levels of IL-10, IL-17 and IL-23 were measured by sandwich ELISA method. Quantitative data are expressed as mean ± standard deviation and median range (maximum-minimum) values. The data were analyzed at 95% confidence interval, and cases where the p value was less than 0.05 were considered statistically significant.</em></p> <p><strong><em>Results:</em></strong> <em>IL-10 and IL-17 levels of the control and patient groups were compared and no statistically significant difference was found </em><em>(p=0.333, </em><em>p=0.99</em><em>).</em> <em>IL-23 levels of the patient group were found to be higher than the control group and were found to be statistically significant (p<0.001).</em><em> No statistically significant relationship was found between disease duration or SLEDAI score and IL-23 levels </em><em>(p=0.476).</em><em> 25 (OH) vitamin D levels of the patient group were found to be lower than the control group and were statistically significant</em><em> (p=0.003). No significant relationship was found between IL-10 and IL-17 levels and vitamin D. Significant relationship was found between IL-23 and vitamin D levels (p=0.019).</em></p> <p><strong><em>Discussion:</em></strong><em> In our study, there was no significant difference between the groups in terms of IL-10 or IL-17, while IL-23 levels were found to be significantly higher in SLE patients. Vitamin D levels were found to be lower in the patient group with SLE compared to the control group, and a negative correlation was found between the disease duration and IL-23. Specific blocking of the IL-23 immune pathway can be an effective and safe treatment option in the treatment of SLE.</em></p>}, number={1}, journal={HEALTH SCIENCES QUARTERLY}, author={Genç Çetin, Beyza and Şentük, Taşkın and Aydın, Neriman}, year={2021}, month={Apr.}, pages={25–30} }